pI: 5.7656 |
Length (AA): 562 |
MW (Da): 62468 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
374 | 536 | 3iev (A) | 142 | 298 | 20.00 | 0 | 0.95 | 0.546736 | -0.27 |
376 | 525 | 2x49 (A) | 449 | 611 | 31.00 | 0.22 | 0.16 | 0.368804 | 0.92 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127948)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G30960 | GTP-binding family protein |
Arabidopsis thaliana | AT5G66470 | GTP-binding protein Era-like protein |
Babesia bovis | BBOV_III008850 | small GTP-binding protein domain containing protein |
Brugia malayi | Bm1_20700 | Hypothetical GTP-binding protein E02H1.2 in chromosome II |
Caenorhabditis elegans | CELE_E02H1.2 | Protein E02H1.2 |
Dictyostelium discoideum | DDB_G0288609 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7488 | CG7488 gene product from transcript CG7488-RA |
Escherichia coli | b2566 | membrane-associated, 16S rRNA-binding GTPase |
Echinococcus granulosus | EgrG_000482150 | Era-like GTP-binding protein. |
Echinococcus multilocularis | EmuJ_000482150 | Era-like GTP-binding protein. |
Homo sapiens | ENSG00000132591 | Era-like 12S mitochondrial rRNA chaperone 1 |
Leishmania braziliensis | LbrM.25.0400 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_250460.1 | 50S ribosome-binding GTPase, putative |
Leishmania infantum | LinJ.25.0460 | hypothetical protein, conserved |
Leishmania major | LmjF.25.0450 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.25.0450 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_03726 | hypothetical protein |
Mycobacterium leprae | ML0631 | Probable GTP-binding protein Era |
Mus musculus | ENSMUSG00000020832 | Era (G-protein)-like 1 (E. coli) |
Mycobacterium tuberculosis | Rv2364c | Probable GTP-binding protein Era |
Mycobacterium ulcerans | MUL_3617 | GTP-binding protein Era |
Neospora caninum | NCLIV_014010 | hypothetical protein, conserved |
Oryza sativa | 9271571 | Os05g0567300 |
Plasmodium berghei | PBANKA_1009000 | GTPase Era, putative |
Plasmodium falciparum | PF3D7_1435800 | GTPase Era, putative |
Plasmodium knowlesi | PKNH_0422400 | GTPase Era, putative |
Plasmodium vivax | PVX_084745 | GTPase Era, putative |
Plasmodium yoelii | PY00616 | GTP-binding protein Era |
Schistosoma japonicum | Sjp_0312390 | ko:K03595 GTP-binding protein Era, putative |
Schistosoma japonicum | Sjp_0305540 | IPR009019,KH, prokaryotic type,domain-containing |
Schistosoma japonicum | Sjp_0114700 | expressed protein |
Schistosoma mansoni | Smp_164220 | GTP-binding protein era |
Schmidtea mediterranea | mk4.063273.01 | GTP-binding protein era, putative |
Schmidtea mediterranea | mk4.002727.04 | GTP-binding protein era, putative |
Trypanosoma brucei gambiense | Tbg972.11.390 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.11.480 | small GTP-binding protein domain containing protein, putative |
Trypanosoma congolense | TcIL3000.11.420 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.507093.184 | small GTP-binding protein domain containing protein, putative |
Toxoplasma gondii | TGME49_286640 | GTPase |
Treponema pallidum | TP0541 | GTP-binding protein Era |
Theileria parva | TP04_0788 | hypothetical protein, conserved |
Wolbachia endosymbiont of Brugia malayi | Wbm0007 | GTP-binding protein Era |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu2405 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.03.0660 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.03.0660 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.03.0660 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.03.0660 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2566 | Escherichia coli | essential | goodall |
TGME49_286640 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.